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In the absence of its ligand neurotrophin-3, the cell surface receptor Trk C acts as a tumor suppressor in neuroblastoma by triggering apoptosis; Marie Ménard, Patrick Mehlen, Servane Tauszig-Delamasure and colleagues show that its caspase-cleaved 'killer fragment' is translocated to the nucleus, interacts with Hey1, and stabilizes p53.
During tumor progression, neutrophils inhibit a tumor-supporting subset of T cells – the interleukin-17-producing γδ T cells.
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Connecting friends, it turns out, is a lucrative game and the two-lady enterprise takes in about 0,000 annually (that includes Institute fees) growing about 25% year over year since 2009.